Treatment of Refractory and Super-refractory Status Epilepticus

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چکیده

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How Refractory is Super-Refractory Status Epilepticus- A Personal View!

The word, super-refectory is coined recently in status epilepticus (SE) when the seizures continue unabated for a day or more, despite rigorous management , leading to subsequent neuronal injury, most of the times and even death [1]. The SuperRefractory Status Epilepeticus is a rare but not uncommon type of ongoing seizure activity and the exact pathophysiology is still not yet studied well. Th...

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Supra-recommendation Treatment of Super-refractory Status Epilepticus

A 28-year old female was admitted with recurrent seizures following 2 days of febrile illness, after which she developed status epilepticus. Midazolam and later thiopentone infusions were started after failure of regular intravenous antiepileptics. Burst suppression was achieved at doses of 3 mg/kg/hr for midazolam and 6 mg/kg/hr of thiopentone. Adjunctive medications included methylprednisolon...

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Ketogenic Diet in Super-Refractory Status Epilepticus

Researchers from the Children's National Health System in Washington, D.C. studied the feasibility, rate of complications, and effect on seizures of initiating the Ketogenic Diet (KD) in pediatric patients with Super-Refractory Status Epilepticus (SRSE).

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Ketogenic diet treatment for pediatric super-refractory status epilepticus

PURPOSE We aimed to study whether ketogenic diet (KD) therapy leads to resolution of super-refractory status epilepticus in pediatric patients without significant harm. METHOD A retrospective review was performed at Phoenix Children's Hospital on patients with super-refractory status epilepticus undergoing ketogenic diet therapy from 2011 to 2015. RESULTS Ten children with super-refractory ...

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The Treatment and Prognosis of Refractory and Super-Refractory Status Epilepticus

Status epilepticus (SE) is one of the most common emergencies in neurocritical care. In Germany, the incidence of SE is about 17/100 000 per year, increasing with age [1]. Especially generalized convulsive (tonic-clonic) status epilepticus (GCSE) is still associated with a high risk of morbidity and mortality [2]. SE is defined as a single prolonged seizure or a series of two or more consecutiv...

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ژورنال

عنوان ژورنال: Neurotherapeutics

سال: 2018

ISSN: 1933-7213,1878-7479

DOI: 10.1007/s13311-018-0640-5